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Updated: Jul 11, 2025

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

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在TRPC3上选择性激活TRPC6离子通道,由金属化B型多环多化酸黄醇激活TRPC3

Philipp Peslalz1, Frank Kraus2, Flavia Izzo2

  • 1Chair of Organic Chemistry, Faculty of Chemistry and Food Chemistry, Technical University Dresden, Bergstr. 66, Dresden 01069, Germany.

Journal of medicinal chemistry
|November 3, 2023
PubMed
概括

新型化合物PPAP53可选择性地激活TRPC6离子通道,为神经退行性疾病和抑郁症提供新的治疗途径. 它的独特结构使其能够精确地与TRPC6 C端结合,并使用人工智能驱动的蛋白质结构预测来阐明.

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