DLBCL:谁有高风险,应该如何优化治疗?
Anna Dabrowska-Iwanicka1, Grzegorz S Nowakowski2
1Department of Lymphoid Malignancies, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Blood
|November 3, 2023
概括
识别高风险的扩散性大B细胞淋巴瘤 (DLBCL) 患者至关重要. 本综述涵盖了新的预后因素和向疗法,以改善DLBCL患者的治疗结果.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 扩散性大B细胞淋巴瘤 (DLBCL),未另有说明,是最常见的侵袭性非霍奇金淋巴瘤.
- 目前的标准疗法是将化疗与rituximab结合起来,在约60%的患者中实现治愈.
- DLBCL在病理,分子和临床特征方面表现出显著的异质性,影响预后.
研究的目的:
- 审查最近在识别高风险DLBCL患者方面的进展.
- 总结新的治疗策略,包括向药物和免疫疗法.
- 讨论前线DLBCL治疗的响应适应策略.
主要方法:
- 对DLBCL最近的临床试验和生物研究的审查.
- 在诊断和治疗期间分析临床和生物预后因素.
- 在DLBCL管理中对向疗法和免疫疗法的评估.
主要成果:
- 对DLBCL生物学的新见解已经完善了风险分层.
- 确定可能从新药中受益的特定患者群体.
- 针对性疗法和免疫治疗方案的开发正在进行中.
结论:
- 准确识别高风险DLBCL对于个性化治疗至关重要.
- 向药物和免疫疗法为DLBCL治疗提供了有前途的新途径.
- 响应适应的策略有可能优化前线DLBCL治疗.
相关概念视频
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Pulmonary Tuberculosis I
246
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
246
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Bone Marrow Sampling and Transplants
339
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
339


