通过优化连接体密度,通过转移素向聚合体抑制多药性耐药性
Shui Ling Yi1, Zi Ling Li1, Yan Chun Gong1
1School of Life Science, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China.
Langmuir : the ACS journal of surfaces and colloids
|November 3, 2023
概括
转移素结合聚合体有效向并抑制多药耐药癌细胞. 最佳的转移林连接体密度可以提高药物输送和抗癌疗效.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 癌症治疗方法 癌症治疗方法
背景情况:
- 癌症中的多药耐药性 (MDR) 对化疗构成了重大挑战.
- 有针对性的药物输送系统可以提高治疗效率并减少副作用.
- 转移素受体介导的内细胞分裂是向癌细胞的有希望的策略.
研究的目的:
- 开发转激素结合聚合体 (Tf-F127-PLA) 用于向输送多克索鲁比 (DOX).
- 为了研究转林配体密度对DOX载荷聚合体的向能力和抗癌疗效的影响.
- 评估这些聚合体对多抗药性癌细胞的抑制作用.
主要方法:
- 使用生物素-阿维丁桥梁技术制备转激素结合的聚合体.
- 将多克索鲁比辛 (DOX) 装入聚合体体中.
- 使用A549肺癌细胞进行细胞毒性和细胞吸收测定.
- 对抗多抗药A549/ADR细胞的抗癌活性的评估.
- 研究细胞内核的机制.
主要成果:
- 与非准对应物相比,Tf-F127-PLA/DOX聚合体表现出增强的准能力.
- 聚合体含有2%的转移素 (Tf) 摩尔含量显示出优异的抗瘤活性和细胞吸收.
- 2%的Tf-F127-PLA/DOX聚合体对抗多药耐药A549/ADR细胞更有效.
- 内细胞分裂是一个依赖能量的过程,涉及克拉,巨细胞分裂和,由转移素受体介导.
结论:
- 转移素结合聚合体代表了癌症治疗的有希望的向药物递送系统.
- 优化转移林连接体密度对于最大化治疗结果至关重要.
- 这些向的聚合体显示出在克服癌细胞多药性耐药性的巨大潜力.
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