年龄对病因学和抗生素敏感性的影响 传染性内膜炎的感染模式
Agimanailiu Khapuinamai1, Vivek Pravin Dave2, Mudit Tyagi2
1Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, India.
Ocular immunology and inflammation
|November 3, 2023
概括
传染性内炎的病因因因年龄而异,在老年患者中观察到抗生素耐药性增加. 范科米辛在阳性感染中仍然有效,但阴性感染需要新的治疗策略.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 传染性内眼炎是一种严重的眼内感染,可能导致视力丧失.
- 了解病原体及其对抗生素的敏感性对于有效管理至关重要.
研究的目的:
- 在不同年龄组的11年内审查传染性内耳炎的病因学和抗生素敏感性模式.
- 确定儿童,成人和老年人群中微生物病原体和抗生素耐药性的趋势.
主要方法:
- 对2011年1月至2021年12月培养阳性内炎病例的微生物学记录的回顾性分析.
- 将患者分为三个年龄组:0-30,31-60,和>60岁.
- 对微生物患病率和抗生素敏感性趋势在年龄组内和年龄组之间进行分析.
主要成果:
- 在5590例临床诊断的内炎病例中,有1316例 (23.5%) 是培养阳性 (1097例细菌,219例真菌).
- 格拉姆阳性细菌占主导地位 (62.6%). 关键的病原体包括*肺炎杆菌 (Streptococcus pneumoniae) * (0-30岁),表皮杆菌 (Staphylococcus epidermidis) * (31-60岁) 和空气真菌 (Pseudomonas aeruginosa) * (>60岁) 等. 黄菌 (Aspergillus flavus) 是所有时代最常见的真菌病原体.
- 对于大多数测试药物,从年轻到年长的年龄组观察到抗生素耐药性的增加趋势,万科和阿米卡显示出一致的有效性.
结论:
- 传染性内炎的病因因因年龄而异.
- 抗生素耐药性模式显示,随着年龄的增长,抗生素耐药性呈上升趋势,需要量身定制的经验治疗策略.
- 虽然万科米辛对抗格拉姆阳性病原体是有效的,但新出现的耐药性和格拉姆阴性生物的流行凸显了对新型治疗选择的需求.
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