儿科患者的Cefiderocol红酒尿综合征:一个多中心病例系列
Kate Shapiro1,2, Stephanie P Ungar3, Jessica Krugman3
1From the Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee.
The Pediatric infectious disease journal
|November 3, 2023
概括
儿童使用Cefiderocol抗生素可能会导致无害的红色或紫色尿液,特别是在输血期间. 这种可能是由于铁相互作用引起的良性副作用,不应被误认为是血.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 儿科 儿科 儿科
背景情况:
- 塞菲德罗科尔是一种新型的类抗生素,有效对抗多药耐药的格拉姆阴性细菌.
- 在儿童中使用Cefiderocol的经验有限.
- 在免疫功能低下的儿科患者中,输血是常见的.
研究的目的:
- 描述一系列儿科患者的病例,这些患者经历了Cefiderocol的特定副作用.
- 为了研究 cefiderocol 和血液制品之间的潜在相互作用.
- 提高对儿童良性尿路变色现象的认识.
主要方法:
- 一系列病例描述了3名免疫受损儿童的情况.
- 在服用 cefiderocol期间观察尿液颜色的变化.
- 对观察到的副作用的潜在机制的审查.
主要成果:
- 在接受输血的3名免疫受损儿童中,在治疗中出现了良性红色或紫色的尿液.
- 尿路变色是短暂的,没有与不良事件相关.
- 假设Cefiderocol和来自血液产品的铁之间的潜在相互作用.
结论:
- 塞菲德罗科尔可以在儿科患者中引起良性红色或紫色的尿液,特别是那些接受输血的人.
- 这种现象很可能是由于血液产品中与铁的相互作用造成的.
- 临床医生应该意识到这种副作用,以避免误诊出血和不必要的调查.
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