呼吸道细菌代码检测对呼吸道通风婴儿患有支气管炎的结果的影响
Manzilat Akande1, Sandra P Spencer2, Melissa Moore-Clingenpeel3
1From the Section of Critical Care, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
The Pediatric infectious disease journal
|November 3, 2023
概括
在患有需要输管治疗的支气管炎的婴儿中,细菌共感染是常见的. 早期的抗生素可能会缩短机械通风的持续时间和重症监护室的停留时间,这需要进一步研究.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 病毒性支气管炎经常导致婴儿急性呼吸衰竭,往往需要输管治疗.
- 与支气管炎同时发生的细菌性呼吸道感染的患病率和影响仍然不清楚,特别是随着呼吸支持策略的发展.
研究的目的:
- 为了调查细菌共检测和婴儿 bronchiolitis 的直管婴儿的临床结果之间的关联.
- 评估细菌共感染对机械通风持续时间和重症监护室 (ICU) 停留时间的影响.
主要方法:
- 一个单一中心的回顾性队列研究包括2岁以下的儿童,需要急诊室输管管道治疗支气管炎 (2012-2017).
- 进行了病毒检测和下呼吸道培养. 细菌的共同检测是由一个积极的培养物和显著的炎症标志物定义的.
- 多变量玛回归分析了细菌密码检测对机械通风 (MV) 持续时间和ICU停留时间的影响.
主要成果:
- 在149名患者中,52%的患者表现出细菌密码检测.
- 细菌密码检测与显著缩短的MV持续时间 (调整后相对风险[aRR] 0.819) 和ICU停留时间 (aRR 0.806) 相关.
- 对通风持续时间的共检测的好处在较早的抗生素给药时更为明显.
结论:
- 细菌共检测在患有需要输管治疗的严重支气管炎的婴儿中很普遍.
- 代码检测与机械通风持续时间和ICU停留时间的减少有关,可能受到早期抗生素使用的影响.
- 进一步的多中心研究对于阐明细菌共检测和抗生素定时在支气管炎管理中的精确作用至关重要.
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