在帕金森病中阻塞性睡眠呼吸暂停的患病率和临床方面:元分析

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Gianpaolo Maggi¹, Chiara Giacobbe¹, Federica Iannotta²

¹Department of Psychology, University of Campania "Luigi Vanvitelli", Caserta, Italy.

European journal of neurology

|November 3, 2023

概括

阻塞性睡眠呼吸暂停 (OSA) 影响近一半的帕金森病 (PD) 患者,通常与年龄,BMI和运动症状有关. 了解这些关联对于管理PD-OSA至关重要.

科学领域:

神经学神经学
睡眠医学睡眠医学
流行病学流行病学

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 在帕金森病 (PD) 中很常见,可能是由于呼吸道问题或共同原因.
OSA可以在PD诊断之前出现或在疾病进展期间恶化.
需要进一步澄清OSA和PD的临床方面 (包括药物治疗) 之间的联系.

研究的目的:

为了确定帕金森病患者 (PD-OSA) 中OSA的患病率.
为了确定与PD-OSA相关的临床因素.
帮助临床医生了解PD-OSA的病理生理学.

主要方法:

在PubMed,Scopus和PsycINFO进行了系统的文献搜索,直到2023年4月.
包括的研究提供了有关患有OSA和没有OSA的PD患者的数据.
患病率被聚合,人口统计学/临床特征被比较在PD患者和没有OSA.

主要成果:

分析包括17项研究,涉及1448名PD患者.
在PD中OSA的综合流行率为45%.
PD-OSA与年龄较大,男性性别,BMI较高,严重的运动障碍,四肢周期性运动,多巴胺激动剂使用和过度的白天嗜睡有关. 此外,还注意到REM睡眠行为障碍的风险降低. 没有发现与认知或神经精神问题的联系.

结论:

OSA在近一半的PD患者中普遍存在,受年龄,BMI和PD运动障碍的影响.
未来的研究应该调查临床特征和多巴胺类药物对PD-OSA发展的影响.

关键词:

帕金森病是帕金森病的一种疾病.多巴胺作用药物药物阻塞性睡眠呼吸暂停 (SOP) 的情况.患病率的流行情况.睡眠障碍睡眠障碍睡眠障碍

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