流和粘度模型对壁切应力产生影响 动脉动脉模拟的衍生生物标志物
Antonio Martínez1, Martijn Hoeijmakers2, Leonardo Geronzi1
1University of Rome Tor Vergata, Rome, Italy; Ansys France, Villeurbanne, France.
Computers in biology and medicine
|November 3, 2023
概括
准确的上升大动脉模拟需要仔细考虑计算方法. 非牛顿粘度显著影响墙壁剪切应力超过流模型,特别是当结合.
科学领域:
- 计算流体动力学的流体动力学.
- 生物医学工程 生物医学工程
- 心血管研究的心血管研究.
背景情况:
- 上升大动脉中患者特有的血液动力学条件对于诊断至关重要.
- 液体生物标志物显示出诊断潜力,但计算方法各不相同.
- 在流和粘度建模中存在差异,影响模拟准确性.
研究的目的:
- 评估流和粘度模型选择对计算流体动力学模拟的综合影响.
- 量化不同建模假设对血液动力学参数的影响.
- 为了建立对上升性大动脉的准确建模要求.
主要方法:
- 计算流体动力学模拟上升的大动脉流动.
- 对非牛顿粘度和大模拟 (LES) 流模型的分析.
- 模拟选择对墙壁剪切应力的综合和孤立效应的比较.
主要成果:
- 非牛顿粘度 (2.9-5.0%) 对墙壁剪切应力的影响比 LES 流模型 (0.1-1.4%) 更大.
- 非牛顿粘度的影响在与子电网规模的流模型相结合时会被放大.
- 牛顿粘度低估了墙壁剪切应力2.9-5.0%.
- 不充分的循环对循环可变性分析可能与数字模型选择一样具有影响力.
结论:
- 计算建模假设的综合效应不同于它们的聚合孤立效应.
- 准确的上升大动脉流量建模需要使用非牛顿粘度和 LES 流模型.
- 了解组合建模效应对于可靠的患者特异性血液动力学评估至关重要.
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