在11只狗中 (2014-2021) 怀疑原发性骨髓T细胞淋巴瘤新生病导致瘤性高血症 (2014-2021)
Alex Portanova1, Emily D Rout2, Anne C Avery2
11Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA.
Journal of the American Veterinary Medical Association
|November 3, 2023
概括
超血症的狗有不明原因的低血细胞计数可能患有起源于骨髓的T细胞淋巴性瘤. 诊断需要骨髓评估,结果各不相同,有些狗经历了长时间的生存.
科学领域:
- 兽医瘤学 兽医瘤学
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 超血是狗的常见临床症状.
- T细胞淋巴瘤新生病可以呈现出各种临床症状.
- 骨髓评估对于诊断某些血液性恶性瘤至关重要.
研究的目的:
- 描述诊断为T细胞淋巴瘤新生病的高血症狗的临床发现和结果.
- 调查骨髓评估对诊断这种疾病的有用性.
- 为了确定潜在的预后因素.
主要方法:
- 在2014年至2021年期间诊断出11只客户拥有的狗的回顾性审查.
- 临床表现分析,血液检查和骨髓诊断 (细胞学,组织学,流细胞计).
- 对治疗方案和生存时间的评估.
主要成果:
- 狗呈现出高血症,多尿症/多滴psia,中性质衰竭和血小板衰竭.
- 骨髓分析显示,所有病例中都出现了瘤T细胞扩张.
- 平均存活时间为260天,结果各不相同.
- 在大多数情况下,在瘤T细胞上观察到CD4表达.
结论:
- 骨髓T细胞淋巴瘤新生病应考虑在高血症的狗中进行细胞衰竭,并且没有外周淋巴细胞分裂或有机巨变.
- 骨髓评估对于诊断至关重要.
- 临床结果是可变的,可能会受到治疗的影响,但延长生存是可能的.
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