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肠道多抗氧化剂活性涉及由水素素活性促进的氧化还原信号机制

Kaiwen Mu¹, David D Kitts¹

¹Food Science, Food Nutrition and Health Program. Faculty of Land and Food System, The University of British Columbia, 2205 East Mall, Vancouver, B.C, V6T 1Z4, Canada.

|November 3, 2023

概括

饮食中的多醇可以通过自氧化产生过氧化 (H2O2) 来作为抗氧化剂. 水素 (AQP) 调节H2O2的吸收,控制肠道细胞的氧化还原稳定和抗氧化反应.

科学领域:

* 食品化学和生物化学
* 细胞生物学和生理学

背景情况:

*饮食中的多醇的双重抗氧化/抗氧化活性仍在争论中.
*细胞氧化还原稳定依赖于平衡的过氧化 (H2O2) 生产和抗氧化系统功能.
*最佳的H2O2水平对于细胞生存至关重要,而过量可以引发炎症或细胞死亡.

研究的目的:

* 探索饮食中的多在肠道细胞平衡中的作用.
* 作为抗氧化活性的先决条件,研究多自氧化产生H2O2的拟议机制.
* 突出水素素 (AQP) 在调节细胞内H2O2吸收和下游信号传递方面的功能.

主要方法:

* 文献综述和综合现有关于多活性,H2O2代谢和水素素功能的研究.
*分析涉及多自氧化和AQP介导的H2O2运输的拟议机制.
* 讨论由氧化聚激活Nrf2通路的激活及其与H2O2信号的并行性.

主要成果:

*多可以自氧化,产生H2O2,这被认为是它们细胞内抗氧化功能的必要步骤.
*水素素 (AQP) 作为肠道的守门人,控制通过多自氧化产生的细胞外H2O2的吸收.
*这种AQP介导的H2O2运输使细胞内信号通路能够减轻氧化应激和炎症.

结论:

*饮食中的多的生物活性由AQP膜功能调节,代表细胞内抗氧化剂化学保护机制.
* 通过多和AQP的受控生成和运输H2O2对于维持肠道氧化还原平衡至关重要.
*对这一机制的进一步研究可能会透露通过饮食和向治疗来管理肠道健康的新策略.

关键词:

亚克瓦波林 (Aquaporin) 是一种水素.肠道健康肠道健康氧化过程中的氧化.聚醇是一种多的化合物.复氧化平衡还原平衡.

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Aquaporins

Aquaporins

Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.

Peroxisomes

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...