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4D DIA-PRM蛋白质组学研究,确定与骨盆器官脱落相关的调节通路和生物标志物

Wei Deng¹, Zhifeng Zhong², Yuehong Tong²

¹Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua 321000, Zhejiang Province, China; Jiangxi Provincial Maternal and Child Health Hospital, Nanchang 330006, Jiangxi Province, China.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

|November 3, 2023

概括

研究人员使用先进的蛋白质组学确定了骨盆器官脱落 (POP) 的关键蛋白质生物标志物. 这项研究增强了对POP POP的理解.

科学领域:

蛋白质组学是指蛋白质组学.
生物化学生化学
妇科妇科医生妇科

背景情况:

骨盆器官脱落 (POP) 显著影响女性的生活质量.
推动POP发展的分子机制尚不清楚.

研究的目的:

为了确定POP的诊断生物标志物.
为了研究底层的分子机制,POP的病原体.

主要方法:

在阴道组织上利用非目标的四维数据独立获取 (4D DIA) 蛋白质组学.
分析了POP患者 (n=19) 和对照组 (n=8) 的组织样本.
通过有针对性的并行反应监测 (PRM) 验证的发现蛋白质组学.

主要成果:

1957年,POP患者的蛋白质发生了显著的改变.
丰富的生物通路包括蛋白质消化/吸收和内分泌卡纳比诺伊德信号传递.
五种蛋白质 (ELN, COL6A2, ENTPD1, AOC3, COX7A2) 显示出高的诊断准确性 (AUC ≥0.95).

结论:

确定了POP的潜在诊断生物标志物,包括ELN,COL6A2,ENTPD1,AOC3和COX7A2.2.
对涉及POP病变发生的分子途径的高级理解.
蛋白质组学为POP诊断和研究提供了一个有前途的方法.

关键词:

生物标志物生物标志物时间时间时间时间波普波普波普波普波普在PRM中,PRM是PRM.蛋白质组学是指蛋白质组学.

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