在精神分裂症相关的神经发育动物模型中,性取决于青春期前社会功能障碍的出现和多巴胺活性增加
Millie Rincón-Cortés1, Anthony A Grace1
1Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, United States.
Schizophrenia research
|November 3, 2023
概括
这项研究揭示了老鼠精神分裂症模型中的性别特异性发育变化. 雄性老鼠表现出早期的社会缺陷,而雌性老鼠则表现出这些精神分裂症相关症状的延迟出现.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展生物学 发展生物学
背景情况:
- 精神分裂症是一种神经发育障碍,在男性中早期发作,并以社会功能障碍为特征.
- 甲基氧甲醇 (MAM) 鼠标模型模仿精神分裂症,显示成人行为和多巴胺 (DA) 系统的变化.
- 高风险年轻人的社会缺陷在精神病之前,作为一种前性标志物.
研究的目的:
- 调查在青春期前期间在雄性和雌性MAM大鼠中出现的社会和DA功能障碍.
- 确定这些缺陷是否因性别而异,并与DA功能受损有关.
- 了解精神分裂症相关的动物模型中社会缺陷的本体性.
主要方法:
- 怀孕大鼠在第17个妊娠日暴露于MAM.
- 在雄性和雌性MAM大鼠 (产后33-43天) 中,社会行为 (游戏,接近) 的表征.
- 在青春期前的MAM大鼠中评估VTA DA神经元活动.
主要成果:
- 雄性MAM大鼠表现出减少的社会接触和增加的VTA DA神经元活动.
- 雌性MAM老鼠表现出增强的游戏行为,但没有改变社交方法或VTA DA神经元活动.
- 观察到社会和DA功能障碍出现的性别特异性差异,女性表现出延迟出现.
结论:
- 在MAM老鼠模型中,在社会和DA功能障碍的本体发生过程中表现出性别特异的模式.
- 这些发现突显了精神分裂症相关缺陷的发育轨迹中的性别差异.
- 在这个模型中,女性可能会经历社会和DA功能障碍的延迟出现.
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