心血管健康和癌症幸存者的死亡率之间的剂量反应相关性
Rubén López-Bueno1, Lin Yang2, Joaquín Calatayud3
1Department of Physical Medicine and Nursing, University of Zaragoza, Zaragoza, Spain; Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia, Valencia, Spain; National Research Centre for the Working Environment, Copenhagen, Denmark.
Current problems in cardiology
|November 3, 2023
概括
改善心血管健康 (CVH) 显著降低癌症幸存者的死亡风险. 美国心脏协会的Life's Essential 8 (LE8) 的高得分与减少全因和心血管疾病 (CVD) 的死亡率有关,但不是癌症死亡率.
科学领域:
- 心血管健康研究研究
- 癌症生存率研究研究的研究.
- 公共卫生和流行病学.
背景情况:
- 对心血管健康 (CVH) 对癌症幸存者死亡率的影响的理解有限.
- 需要确定所有原因,心血管疾病 (CVD) 和癌症死亡率的剂量反应关系.
研究的目的:
- 调查美国成年癌症幸存者中CVH和死亡风险之间的剂量反应关联.
- 评估美国心脏协会的生命必需8 (LE8) 评分对死亡率结果的影响.
主要方法:
- 利用来自美国国家健康和营养检查调查 (NHANES) (2007-2018) 1701名美国成年癌症幸存者的数据.
- 采用美国心脏协会的生命必需品8 (LE8) 作为心血管健康的代理.
- 应用受限立方线模型来分析剂量-反应关联.
主要成果:
- 在LE8得分和全因死亡率之间发现了几乎反向的线性关联,并观察到显著的风险降低.
- 在LE8得分与心血管疾病死亡率之间的反曲线关联显示,风险显著降低.
- 在LE8得分和癌症死亡率之间没有发现显著的剂量反应关联.
结论:
- 根据LE8测量,较高的心血管健康与癌症幸存者的全因和心血管疾病死亡率降低有关.
- 这些发现表明,通过CVH改进计划,可能会对公共卫生产生重大影响.
- 进一步的研究可能会探索具体的干预措施,以增强CVH和减轻这一群体的死亡风险.
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