相关实验视频

Updated: Jul 11, 2025

A Method for Generating Pulmonary Neutrophilia Using Aerosolized Lipopolysaccharide

A Method for Generating Pulmonary Neutrophilia Using Aerosolized Lipopolysaccharide

Published on: December 15, 2014

短期PM_2.5暴露的非线性促炎效应:脂多糖的潜在作用

Fangxia Shen¹, Mutong Niu¹, Haoxuan Chen²

¹School of Space and Environment, Beihang University, Beijing 100191, China.

Journal of environmental sciences (China)

|November 3, 2023

概括

由于其异质性,暴露于颗粒物 (PM2.5) 对健康有非线性影响. 这项研究发现脂聚糖 (LPS) 影响PM2.5

科学领域:

环境健康科学环境健康科学
毒理学毒理学毒理学
分子生物学分子生物学

背景情况:

流行病学研究表明,短期暴露于细颗粒物 (PM2.5) 和健康影响之间存在非线性联系.
假设这种非线性源于PM2.5异质性,但潜在的生物机制仍然不清楚.

研究的目的:

从预炎症的角度研究PM2.5暴露对人类单细胞衍生的巨细胞 (THP-1) 的短期影响.
探索PM2.5的促炎潜力的异质性及其与脂聚糖 (LPS) 等化学成分的关系.

主要方法:

在冬季的三个星期里从北京收集了38个PM2.5过器.
用PM2.5水溶性化物治疗的THP-1细胞和测量瘤死因子 (TNF) 生产.
分析了PM2.5成分 (特别是LPS) 与TNF异质性之间的关联,包括基因表达分析.

主要成果:

在PM2.5化剂中,诱导的炎症性细胞因子TNF水平不均,表明炎症性潜在的异质性.
脂聚糖 (LPS) 显示出与TNF异质性的强烈积极关联,但观察到异常值.
提出了一种潜在的氧化压力中介抑制机制,以解释TNF水平的降低,尽管在清洁空气中出现更高的LPS.

结论:

从基于组分的角度来看,LPS在PM2.5的炎症效应异质性中起着不同的作用.
氧化应激可以调节PM2.5传播的LPS的炎症影响.
需要进一步的研究,以充分阐明来自不同空气质量条件的PM2.5附加的LPS的信号通路.

关键词:

气溶对健康的影响最后毒素 (Endotoxin) 是一种内毒素.很好总理总理氧化应激是一种氧化应激.PM(2.5) 有助于炎症的作用.

更多相关视频

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation

Published on: July 6, 2019

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

相关概念视频

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

Formation of Lipopolysaccharides

Formation of Lipopolysaccharides

Lipopolysaccharides (LPS) are crucial components of the outer membrane of Gram-negative bacteria, serving both structural and functional roles. It contributes to membrane stability and protects bacteria from host immune responses. LPS is composed of three major regions—lipid A, a core oligosaccharide, and an O antigen. The biosynthesis and assembly of LPS involve a highly coordinated set of enzymatic reactions and transport mechanisms. Additionally, LPS is recognized as an endotoxin,...