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Updated: Jul 11, 2025

Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions
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Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions

Published on: June 7, 2020

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DNAJB6突变体通过与Hsp70伴侣的不受管制的相互作用来表现出有毒的功能增长

Meital Abayev-Avraham1, Yehuda Salzberg2, Dar Gliksberg1

  • 1Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, 761000, Israel.

Nature communications
|November 4, 2023
PubMed
概括

DNAJB6中的突变通过破坏Hsp70的伴侣相互作用,导致蛋白质稳定性损失,导致LGMDD1. 针对这种DNAJB6-Hsp70结合的治疗策略显示出治疗这种肌肉衰竭的前景.

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In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells00:08

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