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Updated: Jul 11, 2025

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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人类ClpP的选择性激活剂触发细胞循环停止,以抑制肺状细胞癌

Lin-Lin Zhou1,2, Tao Zhang1, Yun Xue3,4

  • 1State Key Laboratory of Drug Research, Centre for Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Nature communications
|November 4, 2023
PubMed
概括

一种新型化合物,ZK53,可以选择性地激活线粒体ClpP,为肺状细胞癌提供一种新的治疗策略. 这种激活剂通过破坏瘤细胞的能量产生和诱导DNA损伤来证明体内有效性.

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