在中年和老年人中,鉴定与一般认知功能相关的循环蛋白质
Adrienne Tin1,2, Alison E Fohner3,4,5, Qiong Yang6
1Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA. atin@umc.edu.
Communications biology
|November 4, 2023
概括
研究人员确定了246种与认知功能相关的循环蛋白,其中45种是复制的. 较高的NECTIN2蛋白水平与阿尔茨海默氏症的增加相关.
科学领域:
- 蛋白质组学是指蛋白质组学.
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
背景情况:
- 识别与认知功能相关的循环蛋白质对于理解认知障碍至关重要.
- 很少有研究探讨了循环蛋白和认知表现之间的联系.
- 认知障碍和阿尔茨海默病 (AD) 构成了重大的公共卫生挑战.
研究的目的:
- 识别与一般认知功能相关的循环蛋白质指标.
- 研究特定蛋白质与阿尔茨海默病 (AD) 风险之间的因果关系.
- 探索对认知障碍和AD的潜在治疗点.
主要方法:
- 使用 SomaScan 试验量化 246 种蛋白质测量,最多 7289 名参与者.
- 使用独立的 SomaScan 和 Olink 数据集重复发现.
- 进行了丰富分析和孟德尔随机化,以推断因果关系.
主要成果:
- 确定了246种与认知功能相关的蛋白质测量方法 (p < 4.9E-5).
- 用SomaScan数据复制了45种蛋白质,用Olink数据复制了3种.
- 门德尔随机化意味着更高的NECTIN2水平与AD风险增加 (p = 2.5E-26);14种蛋白质是AD易感性的结果.
结论:
- 循环中的蛋白质,特别是NECTIN2,与认知功能和AD风险有关.
- 被认为是AD易感性的原因或后果的蛋白质提供了对免疫-AD联系的见解.
- 这些发现突出了潜在的新生物标志物和认知障碍的治疗点.
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