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怀孕期间重金属暴露对出生结果的影响

Sabrina Shafi Zinia¹, Ki-Hyeok Yang¹, Eun Ju Lee¹

¹Department of Internal Medicine and Environmental Health Center, School of Medicine, Kangwon National University, Chuncheon, 24341, Republic of Korea.

Scientific reports

|November 4, 2023

概括

产前接触有毒重金属与婴儿出生体重降低有关. 这项研究强调了即使在低暴露水平的风险,强调了怀孕期间环境健康监测的必要性.

科学领域:

环境健康环境健康
生殖毒理学生殖毒理学
儿科健康儿科健康

背景情况:

,和等重金属对健康构成重大风险,特别是对孕妇和正在发育的胎儿.
了解产前接触这些有毒物质对婴儿出生结果的影响对于公共卫生至关重要.

研究的目的:

调查母亲暴露于,和与韩国婴儿出生结果之间的联系.
检查重金属度对出生体重的影响,对于妊娠年龄来说小 (SGA),对于妊娠年龄来说大 (LGA) 状态.

主要方法:

分析了参与韩国儿童环境健康 (Ko-CHENS) 研究 (2015-2019) 的5215名孕妇的数据.
利用线性和逻辑回归模型来评估重金属暴露的影响,并根据许多母婴共变量进行调整.
进行金属之间的相互调整,以隔离对出生体重和LGA状态的个人影响.

主要成果:

孕产妇暴露与早 (β = -39.96) 和晚期怀孕 (β = -37.24) 的出生体重降低显著相关.
怀孕早期的暴露也与妊娠年龄大 (LGA) 状态 (调整后OR=0.637) 的可能性增加有关.
研究结果表明,产前暴露与低出生体重之间存在显著的关联,即使在低暴露水平.

结论:

产前暴露是产生不良出生后果的重要危险因素,特别是出生时体重低.
该研究强调了监测和减轻怀孕期间暴露的重要性,以改善婴儿健康.
需要进一步研究对胎儿发育的具体机制和低剂量影响.

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