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在极度早产的儿童中,语言表现和大脑体积,不对称性和皮质厚度
Hedvig Kvanta1, Jenny Bolk2,3,4, Lina Broström4
1Department of Women's and Children's Health, Karolinska Institutet, Solna, Stockholm, Sweden. hedvig.kvanta@ki.se.
Pediatric research
|November 4, 2023
概括
极度早产 (EPT) 出生的儿童在语言区域显示大脑体积和皮质厚度减少. 在EPT儿童中,大脑体积与语言结果有关,突出显示了影响语言发育的结构差异.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 放射学 放射学是一门学科.
背景情况:
- 过早出生的孩子往往会遇到语言困难.
- 有限的研究存在于极度早产 (EPT) 儿童的语言相关的大脑结构,与期生同龄人相比.
研究的目的:
- 为了研究与语言相关的区域的结构性大脑差异,在EPT出生的孩子和到期出生的对照之间.
- 探索这些结构差异与EPT儿童语言结果之间的关联.
主要方法:
- 用T1加权的MRI扫描来评估50名EPT儿童的脑体积,不对称性和皮质厚度,以及37名10岁的出生后对照.
- 语言能力在12岁时被评估,使用儿童韦克斯勒智力表和语言基础临床评估.
主要成果:
- 出生于EPT的儿童在与语言相关的区域中表现出大脑体积和皮质厚度的减少.
- 在EPT和满期出生组之间没有发现体积不对称的显著差异.
- 在EPT儿童中,大脑体积与语言结果相关,然后调整为全方位智商.
结论:
- 结构性大脑差异,特别是语言区域的体积和厚度减少,存在于出生于EPT的儿童中.
- 大脑体积是EPT儿童语言结果的重要相关因子.
- 这些发现增强了对EPT个体大脑成像和语言发育之间的结构功能关系的理解.
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