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基线患病率和自主功能障碍在早期帕金森病的纵向评估

Lanqing Yang¹, Huan Gao¹, Min Ye²

¹Department of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, 210019, Jiangsu, China.

Journal of neural transmission (Vienna, Austria : 1996)

|November 4, 2023

概括

在早期帕金森病 (PD) 患者中,自主功能障碍 (AutD) 在两年内恶化,与健康对照不同. 较高的非运动性症状得分预测了PD中的自闭症进展.

科学领域:

神经学神经学
临床神经科学临床神经科学

背景情况:

自主功能障碍 (AutD) 是帕金森病 (PD) 的常见和致残的非运动症状.
在PD中AutD的预测因子和生物相关性仍然不完全理解.
在早期未经治疗的PD中,对AutD进展的纵向数据是有限的.

研究的目的:

确定与健康对照组 (HC) 相比,在新发病的PD患者中AutD的基线患病率和2年进展.
确定早期PD中AutD纵向变化的临床和生物预测因素.

主要方法:

利用了来自帕金森病进展标记计划 (PPMI) 队列的数据.
在基线和2年随访时使用帕金森病-自主性 (SCOPA-AUT) 结果评分表进行自主功能评估.
与自闭症严重程度相关的基线和纵向临床 (MDS-UPDRS Part I) 和生物 (CSF生物标志物) 变量.

主要成果:

在PD患者中,自主功能障碍在2年内显著恶化 (p < 0.001),而在HC患者中保持稳定.
较高的基线SCOPA-AUT分数与较高的基线MDS-UPDRS第I部分分数相关 (p < 0.001).
自闭症严重程度的纵向增加与白人相关 (p = 0.010),但与CSF生物标志物无关.

结论:

自主功能障碍在早期帕金森病中是渐进的.
非运动症状,特别是通过MDS-UPDRS第I部分测量的症状,可以预测AutD的进展.
种族是影响自闭症发展到PD的潜在因素,而CSF生物标志物在这个队列中没有显示出预测价值.

关键词:

自主性的功能障碍.生物标志物生物标志物这就是为什么PPMI是PPMI.帕金森病是帕金森氏症的一种疾病.这里是SCOPA-AUT的位置.

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