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冠状动脉疾病患者肠道微生物群和宿主转录组的变化
Liuying Chen1, Xuanting Mou1, Jingjing Li2
1Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
BMC microbiology
|November 4, 2023
概括
肠道微生物与冠状动脉疾病 (CAD) 风险有关. 特定的细菌和与它们相互作用的宿主基因显示出用于早期CAD检测的新生物标志物的潜力.
科学领域:
- 基因组学就是基因组学.
- 微生物学 微生物学
- 心血管医学 心血管医学
背景情况:
- 冠状动脉疾病 (CAD) 影响全球数百万人,由于缺乏特定的生物标志物,早期检测受到阻碍.
- 肠道微生物群在CAD病变发生过程中的作用仍未得到充分研究.
- 主体微生物群相互作用越来越多地被认为对人类健康的影响.
研究的目的:
- 研究宿主基因和肠道微生物在冠状动脉疾病 (CAD) 中的协同作用.
- 为了确定潜在的微生物和遗传生物标志物用于早期CAD检测.
- 揭示肠道微生物群和宿主遗传因素在CAD中的相互作用.
主要方法:
- 收集了CAD患者和健康对照的便和血液样本.
- 执行了安普利康和转录基因测序.
- 利用随机森林分析来识别生物标志物和整合基因组数据.
主要成果:
- 不调节的肠道微生物与CAD有显著的关联.
- 20种细菌和30种基因生物标志物的组合能够高精度地区分出CAD患者 (AUC=0.92).
- 特定的肠道微生物,如Fusicatenibacter,显示与CAD风险基因和免疫相关途径的关联.
结论:
- 不调节的肠道微生物通过与宿主基因的相互作用,导致CAD风险.
- 已识别的肠道微生物和相互作用的风险基因有可能成为CAD的新生物标志物.
- 这些发现强调了肠道微生物群在心血管健康和疾病中的重要性.
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