从感知到面部衰老的表观遗传学的见解
Klemo Vladimir1,2, Marija Majda Perišić1,3, Mario Štorga1,3
1LifeNome Inc., New York, 10018, NY, USA.
Clinical epigenetics
|November 4, 2023
概括
这项研究确定了血液甲基化标志物,这些标志物会影响你的脸看起来多么老. 这些发现可能会导致新的抗衰老策略,针对皮肤衰老的根本原因.
科学领域:
- 遗传学和表观遗传学
- 皮肤病学 皮肤病学
- 衰老研究研究 衰老研究
背景情况:
- 面部衰老是生物衰老的可见指标.
- 表观遗传钟使用甲基化标记物估计生物年龄.
- 表观遗传生物标志物在面部衰老中的因果作用仍然不清楚.
研究的目的:
- 为了研究血液甲基化标记物和感知到的面部衰老之间的因果关系.
- 识别特定的表观遗传生物标志物 (CpG),驱动或保护面部衰老.
- 探索血液甲基化标记物的潜力,以量化皮肤衰老和开发抗衰老干预措施.
主要方法:
- 整合全基因组关联研究 (GWAS) 对感知面部衰老和全表观基因组关联研究 (EWAS) 对血液CpG.
- 应用孟德尔随机化 (MR) 来推断CpG与面部衰老之间的因果关系.
- 对与现有的表观遗传钟重叠的候选因果性CpG的分析及其与皮肤衰老相关基因的关联.
主要成果:
- 已经确定了数百种假定CpG与感知到的面部衰老有因果关系.
- 发现了加速衰老和减缓衰老的甲基化标志物.
- 候选因果CpG与已知的表观遗传钟有有限的重叠,但针对的基因涉及皮肤色素,弹性素和原.
结论:
- 血液甲基化标记体现了潜在的面部衰老过程.
- 已识别的CpG有可能成为皮肤衰老的生物标志物.
- 这些发现为开发针对性抗衰老解决方案铺平了道路,解决了皮肤衰老的根本原因.
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