小RNAs,精子生成和男性不孕症:十年的回顾
Meghali Joshi1,2, Shruti Sethi1,2, Poonam Mehta1,2
1Division of Endocrinology, Central Drug Research Institute, Lucknow, Uttar Pradesh, India.
Reproductive biology and endocrinology : RB&E
|November 4, 2023
概括
小型非编码RNAs (sncRNAs) 对于男性生殖至关重要,在精子发育过程中调节基因表达. 这些sncRNAs,包括microRNAs和piRNAs,显示出作为精子质量和生育问题的生物标志物的潜力.
科学领域:
- 生殖生物学 生殖生物学
- 分子遗传学 分子遗传学
背景情况:
- 小型非编码RNAs (sncRNAs) 是生物系统中关键的基因表达调节者.
- 在男性生殖中,sncRNAs起着至关重要的作用,包括生殖细胞的维护,半转化和精子的发育.
- 微RNAs (miRNAs),PIWI相互作用RNAs (piRNAs),小干扰RNAs (siRNAs) 和转移RNA衍生的小RNAs (ts-RNAs) 是精子生成中突出的sncRNAs.
研究的目的:
- 审查sncRNAs在精子生成中的多方面的作用.
- 探索sncRNA失调与男性不孕症之间的关联.
- 讨论精子携带的sncRNAs作为生育能力和精子质量的生物标志物的潜力.
主要方法:
- 关于男性生殖和不孕症中sncRNAs研究的文献综述.
- 对各种sncRNA类 (miRNA,piRNA,tsRNA) 在生殖细胞发育中的已知功能进行分析.
- 评估证据,将sncRNA失调与不孕症联系起来.
主要成果:
- 在精子生成过程中,sncRNAs对于调节基因表达至关重要.
- 超过100个miRNAs的失调与不孕症有关,而piRNA和tsRNA的作用研究较少.
- 成熟的精子携带sncRNAs,特别是miRNAs和tsRNAs,这些sncRNAs是在表皮质成熟过程中获得的.
结论:
- sncRNAs是男性生殖过程的重要调节者.
- 异常的sncRNA表达与男性不孕症有关.
- 精子传递的sncRNAs代表了评估精子质量和生育潜力的有希望的生物标志物.
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