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人类iPSC衍生的神经元模型对早期发病的阿尔茨海默病的局限性

Phoebe Valdes1,2, Kenneth W Henry3,4, Michael Q Fitzgerald1,2

  • 1Department of Bioengineering, University of California, La Jolla, San Diego, CA, USA.

Molecular brain
|November 4, 2023
PubMed
概括

使用诱导多能干细胞 (iPSCs) 的早期阿尔茨海默病 (EOAD) 模型可能无法准确地反映零星的AD. 重编程iPSC可能会删除关键的表观遗传特征,限制它们对研究这种形式的阿尔茨海默病的有用性.

关键词:
早期发病的阿尔茨海默氏病.在RNA-seqqq.系统生物学 系统生物学的 iPSC 神经元.

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