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移植后癌症死亡率:意大利的一项多中心队列研究
Martina Taborelli1, Diego Serraino1, Claudia Cimaglia2
1Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.
International journal of cancer
|November 4, 2023
概括
与普通人群相比,移植接受者面临的癌症死亡风险明显更高. 这项研究强调了淋巴瘤,脏和皮肤癌的风险增加,强调了改善癌症监测的必要性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 接受移植 (KT) 的人患各种癌症的风险较高.
- 在KT接受者的癌症死亡率数据仍未得到充分研究.
- 这项研究探讨了意大利KT接受者癌症死亡率的研究不足的方面.
研究的目的:
- 评估意大利KT接受者的癌症死亡风险.
- 为了将KT接受者的癌症死亡率与意大利普通人口进行比较.
主要方法:
- 一项队列研究,涉及2003年至2020年期间的7373名意大利知识技术接受者.
- 死亡日期和死亡原因的数据收集到2020年12月31日.
- 间接标准化用于计算标准化死亡率 (SMR) 和置信区间 (CI).
主要成果:
- 在KT接受者中,癌症是死亡的主要原因 (32.4%).
- 对于所有癌症综合而言,观察到1.8倍的过度死亡率 (SMR=1.8).
- 淋巴瘤 (SMR=6.17),癌 (SMR=5.44) 和皮肤黑色素瘤 (SMR=3.19) 的风险过剩最高.
- 肺癌,乳腺癌和膀癌的SMR增加也被注意到.
- 癌症死亡风险在所有年龄组中仍然较高,并且随着时间的推移呈现线性增加.
结论:
- 接受康复疗法的人比普通人群癌症死亡风险明显高.
- 特定的癌症,如淋巴瘤和癌,具有很大的风险.
- 这些发现强调了加强癌症预防和癌症早期检测策略的必要性.
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