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Updated: Jul 11, 2025

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
10:01

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

Published on: November 28, 2017

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开发一种自动化,高通量方法,用于原生质谱和碰撞诱导的展开

Brock R Juliano1, Joseph W Keating1, Henry W Li1

  • 1Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.

Analytical chemistry
|November 4, 2023
PubMed
概括

我们开发了一种使用RapidFire机器人样本处理的自动化高通量方法,用于本地离子移动性质谱 (nIM-MS) 和碰撞诱导展开 (CIU). 这种方法显著增加了生物分子结构和稳定性分析的吞吐量.

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