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在VEGFA和VEGFR2基因中的遗传多态性与冠状动脉心脏病易感性和严重性相关
Foddha Hajer1, Saoud Hana2, Chouchene Saoussen3,4
1Laboratory of Human Genome and Multifactorial Diseases (LR12ES07), Faculty of Pharmacy, University of Monastir, Monastir, Tunisia. hajer.foddha@hotmail.fr.
Molecular biology reports
|November 4, 2023
概括
血管内皮生长因子A (VEGFA) 和VEGFR2通路中的遗传变异与冠心病 (CHD) 的发展和严重程度有关. 在VEGFA和VEGFR2基因中的特定单核酸多态 (SNP) 可能会增加心脏病风险和病变严重程度.
科学领域:
- 心血管遗传学 心血管遗传学
- 分子生物学分子生物学
- 心血管疾病的病理生理学
背景情况:
- 血管内皮生长因子A (VEGFA) 通过其受体VEGFR2.2促进血管生成.
- 缺血激活了VEGFA/VEGFR2通路,冠心病 (CHD) 患者的VEGFA水平升高.
- 这项研究研究了特定的VEGFA和VEGFR2基因单核酸多态 (SNP) 在心脏病发展中的作用.
研究的目的:
- 确定VEGFA (rs3025039,rs699947) 和VEGFR2 (rs2305948,rs1870377) 中四个SNP对心血管疾病易感性的贡献.
- 为了评估这些SNP与冠状动脉病变的严重程度之间的关联,使用Gensini评分.
主要方法:
- 一项涉及239名心血管疾病患者和200名对照者的病例控制研究.
- 使用聚合酶连锁反应-限制片段长度多态化,进行了SNP的基因定型.
- 统计分析考虑了年龄,性别,吸烟行为和肥胖.
主要成果:
- SNP rs699947 (VEGFA) 和 rs1870377 (VEGFR2) 显示出与慢性心脏病的显著等位基关联.
- 在调整后的衰退模型下,SNP rs3025039 (VEGFA) 显示出与CHD的潜在关联.
- 两种VEGFASNP (rs699947和rs3025039) 都与更高的根西尼分数有显著的关联,表明损伤严重程度增加.
结论:
- 在心血管疾病中,VEGFA/VEGFR2信号通路可能被下调,从而增加敏感性.
- 特定的VEGFA和VEGFR2基因变异与心脏病风险和严重程度有关.
- 这些发现有助于理解CHD病理生理学的遗传基础.
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