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对患有超IgE综合征的患者恶性瘤患病率的系统审查

Tayebeh Mohammadi¹, Gholamreza Azizi¹, Hosein Rafiemanesh¹

¹Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.

Clinical and experimental medicine

|November 4, 2023

概括

超IgE综合征 (HIES) 与6.5%的恶性瘤率有关,特别是在女性和具有DOCK8突变的人群中. 这凸显了HIES患者常规癌症查的必要性.

科学领域:

免疫学免疫学免疫学
遗传学遗传学是一种遗传学.
在瘤学瘤学.

背景情况:

超免疫球蛋白E综合征 (HIES),也称为乔布综合征,是一种原发性免疫缺陷.
HIES基本上是由STAT3基因突变引起的,但也可能是其他遗传缺陷的结果.
恶性瘤,特别是淋巴瘤,在HIES患者中越来越多地被认为是并发症.

研究的目的:

系统地审查和分析HIES患者恶性瘤的患病率.
在HIES中识别与恶性瘤发展相关的因素.
在HIES中为癌症查提供临床实践信息.

主要方法:

系统审查到2023年4月在Scopus,PubMed和Web of Science上发表的文章.
来自26篇选定的文章的数据的元分析,包括来自1133名HIES患者的人口和恶性病症信息.
由三个独立研究人员进行数据提取和分析.

主要成果:

总共有6.5%的HIES患者 (96分之1133) 被诊断出至少有一种恶性瘤.
非霍奇金淋巴瘤 (NHL) 的患病率为2.9%,状细胞癌 (SCC) 的患病率为2.2%.
恶性瘤在女性和具有DOCK8突变的个体中更为普遍.

结论:

HIES与恶性瘤的显著风险有关,发生在6.5%的病例中.
医生应考虑对HIES患者进行恶性查,特别是女性和具有DOCK8突变的患者.
需要进一步的研究来阐明确切的风险因素和改善管理策略.

关键词:

在HIES综合征中,在 IgE 中,IgE 是约伯综合症是什么意思约伯综合症恶性瘤是一种恶性瘤.主要免疫缺陷是一个主要的免疫缺陷.

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