差异Ire1决定了瘤抑制细胞竞争中的输家细胞命运
Jiadong Zheng1, Yifan Guo1, Changyi Shi2
1Fudan University, Shanghai 200433, China; Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310024, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang 310024, China.
Cell reports
|November 4, 2023
概括
抑制瘤的细胞竞争消除了致癌细胞. 展开的蛋白质反应的Ire1通路关键地控制了这个过程,影响了癌细胞的消除和周围细胞的行为.
科学领域:
- 细胞生物学 细胞生物学
- 癌症研究 癌症研究
- 发育生物学是发展生物学.
背景情况:
- 瘤抑制细胞竞争 (TSCC) 是对瘤发生的自然防御.
- 展开的蛋白质反应 (UPR) 在癌症中的作用仍然存在争议.
- UPR的Ire1分支涉及各种细胞过程.
研究的目的:
- 调查UPR的IRE1分支机构在写字 (写字) 损失引起的TSCC中的作用.
- 确定Ire1信号如何影响TSCC期间的致癌细胞和周围细胞.
- 探索Ire1在跨物种TSCC中的保护作用.
主要方法:
- 使用Drosophila melanogaster眼皮作为一个模型系统.
- 在SCRIB突变克隆中操纵Ire1活动 (突变和过度激活).
- 在Ire1调节的反应中评估了亡和自诱导.
- 研究了Ire1在哺乳动物细胞竞争模型中的作用.
主要成果:
- 在scrib克隆中Ire1突变和过度活化分别通过亡和自加速了它们的消除.
- 调节周围细胞中的Ire1活性,通过减少亡,扭转了scrib克隆的"失败者"地位.
- 发现Ire1对于哺乳动物细胞中的细胞竞争至关重要,这表明功能得到保护.
结论:
- UPR的IRE1分支机构在监管scrib介导的TSCC方面发挥着决定性的作用.
- 在细胞竞争期间,Ire1活动对于确定输家细胞命运至关重要.
- 这些发现为TSCC提供了分子洞察力,并将Ire1确定为关键的调节器.
相关概念视频
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
Loss of Tumor Suppressor Gene Functions
4.8K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.8K
Cancer-Critical Genes II: Tumor Suppressor Genes
7.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.4K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Diversity in Cell Signaling Responses
6.4K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...
Graded and Abrupt Responses
Some signaling systems generate...
6.4K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K


