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Updated: Aug 8, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
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在高脂肪饮食养期间,在白脂肪组织中早期的巨介导Bdnf表达

Kurumi Sakata1, Takehiro Kobayashi1, Saki Yokokura1

  • 1Laboratory of Molecular Neuroscience, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki, Gunma, 370-0033, Japan.

Biochemical and biophysical research communications
|November 4, 2023
PubMed
概括

高脂肪饮食增加了白色脂肪组织 (WAT) 中的大脑衍生神经营养因子 (BDNF),与体重增加相关. 巨细胞调解了这种早期肥胖反应,这表明BDNF在WAT中发挥了新的作用.

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Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
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