失眠与大血管封闭急性缺血性中风之间的关联:一项观察性研究
Huali Xu1, Weili Li2, Jiahao Chen3
1Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong Province, China; Department of Neurology, Binzhou Central Hospital, Binzhou Medical College, Binzhou, Shandong Province, China.
Clinics (Sao Paulo, Brazil)
|November 4, 2023
概括
失眠与患有大血管封闭急性缺血性中风 (AIS) 的患者的治疗结果更差有关. 这可能涉及炎症和氧化应激,强调需要进一步研究睡眠.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 心血管研究研究心血管研究
背景情况:
- 大血管封闭 (LVO) 和急性缺血性中风 (AIS) 是一种需要及时干预的危急情况.
- 预先存在的失眠对AIS临床结果的影响仍然不完全理解.
- 将失眠与中风严重程度联系在一起的潜在机制,如炎症和氧化应激,需要调查.
研究的目的:
- 调查LVO AIS患者的失眠和临床结果之间的关联.
- 探索炎症和氧化应激在这种关联中的潜在作用.
主要方法:
- 分析了508名患有LVO的AIS患者的队列,这些患者正在接受内血管治疗.
- 根据雅典失眠量表,患者被分为失眠和非失眠组.
- 包括NIHSS得分,早期神经系统恶化,不良事件,预后和死亡率在内的结果使用回归分析进行了比较.
主要成果:
- 在AIS患者中,39.6%的患者有失眠.
- 失眠组的90天预后明显差,24小时和7天的NIHSS得分更高,神经系统早期恶化增加,不良事件发生率更高.
- 虽然失眠组的90天死亡率较高,但这种差异在统计学上并不显著.
结论:
- 失眠与LVO AIS患者的临床结果较差显著相关.
- 炎症和氧化应激是潜在的潜在机制,可能会调解失眠对AIS结果的负面影响.
- 需要进一步的研究来阐明这些机制,并制定有针对性的干预措施.
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