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Updated: Jul 11, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

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最近在通过PROTACs和替代向蛋白质降解技术降解膜蛋白的进展

Siyu Chen1, Jingliang Cui1, Haiyan Chen1

  • 1Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Hubei Engineering Research Center for Advanced Fine Chemicals, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, 206 1st Rd Optics Valley, East Lake New Technology Development District, Wuhan, Hubei, 430205, China.

European journal of medicinal chemistry
|November 4, 2023
PubMed
概括

向蛋白降解 (TPD) 提供了一种新的癌症治疗方法,克服药物耐药性. 像PROTACs和LYTACs这样的新方法专门降解引起疾病的膜蛋白,推进癌症治疗策略.

关键词:
在 AbTAC 里, AbTAC 在 AbTAC 里.癌症治疗治疗 癌症治疗在LYTAC中,我们可以使用LYTAC膜蛋白降解降解的过程分子粘合剂是一种分子粘合剂.在Nano-PROTAC中使用.这就是PROTAC.在TPD中,TPD是TPD.

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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs10:44

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