癌症风险,疾病修饰疗法和多发性硬化症的年龄:一项基于人口的回顾性队列研究
Jamie Greenfield1, Luanne M Metz1, Amir Khakban2
1Department of Clinical Neurosciences, University of Calgary, 9th Floor South Tower, Foothills Medical centre, 1403 29 Street NW, Calgary, AB T2N 2T9, Canada.
Multiple sclerosis and related disorders
|November 4, 2023
概括
多发性硬化症 (MS) 患者接受疾病修饰疗法 (DMT) 的癌症风险与普通人群相似. 然而,DMT的使用
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 药理流行病学 药理流行病学
背景情况:
- 对于使用现代疾病修饰疗法 (DMT) 的多发性硬化症 (MS) 患者的癌症结局的长期安全数据至关重要.
- 调查DMT暴露与MS癌症风险之间的潜在联系对于患者护理至关重要.
研究的目的:
- 确定疾病修饰疗法 (DMT) 暴露是否会增加患有多发性硬化症 (MS) 患者侵入性癌症的风险.
主要方法:
- 分析了来自加拿大阿尔伯塔省 (2008-2018) 的基于人口的行政健康数据.
- 疾病修饰疗法 (DMT) 暴露被归类为任何DMT,或特定类型:调节,隔离和耗尽.
- 通过将多发性硬化患者与普通人群 (标准化发病率) 和未暴露的多发性硬化患者 (危险率) 进行比较来评估癌症风险.
主要成果:
- 该研究包括14313例多发性硬化病例,其中40.5%暴露于DMT.
- 在MS群体和普通人群之间,或在DMT暴露的MS病例和普通人群之间,没有观察到癌症风险的总体差异.
- 对于任何DMT和调节DMT,都发现了年龄相关的相互作用,这表明62岁以上的MS患者患癌症风险增加,年轻人具有保护作用.
结论:
- 与普通人群相比,接受疾病修饰疗法 (DMT) 治疗的多发性硬化症 (MS) 患者的癌症风险没有增加.
- 观察到DMT对MS癌症风险的年龄相关影响,需要进一步调查以确定因果关系.
- 在年轻的MS患者中,DMT可能会对癌症产生保护作用,同时在老年患者 (62岁以上) 中可能会增加风险.
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