与中风患者风险因素相关的脑白质变化的分布与中风患者的风险因素相关
Askiel Bruno1, Pranav Prabu2, Kishore Vedala2
1Department of Neurology, Medical College of Georgia at Augusta University, Augusta, GA, United States.
Clinical neurology and neurosurgery
|November 4, 2023
概括
左心室缩 (LVH) 与大脑年龄相关白质变化 (ARWMC) 的分布没有相关性. 较低的家庭收入和脂质水平与中风患者的表面ARWMC分布有关.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 放射学 放射学是一门学科.
背景情况:
- 大脑与年龄相关的白质变化 (ARWMC) 分布可能表明潜在的原因和指导干预.
- 左心室缩 (LVH) 是一种不控制高血压的标志物,研究了它与ARWMC分布的关联.
研究的目的:
- 确定LVH和其他风险因素是否与大脑ARWMC的分布有关.
- 分析LVH,临床因素和表面ARWMC指数之间的关系.
主要方法:
- 分析了来自医院注册的172名急性中风患者的大脑MRI数据.
- 使用ARWMC尺度,ARWMC病变被分为表面或深层,并计算了表面ARWMC指数.
- 回归分析评估了LVH和临床因素与表面ARWMC指数的独立关联,但不包括下和双边中风.
主要成果:
- 较高的表面ARWMC指数与较低的家庭收入 (OR 10.72),较低的低密度胆固醇 (LDL) (OR 0.86) 和较低的甘油三 (TG) 水平 (OR 0.91) 有关.
- 双变量分析显示ARWMC分布与年龄较大,家庭收入较低和血清TG水平较低有关.
- 接收器运行特征分析表明,家庭收入,LDL和TG水平的预测值中等.
结论:
- 没有发现左心室缩 (LVH) 与该队列中大脑ARWMC的分布有关.
- 通过使用替代ARWMC分类和更大的样本大小进行进一步的研究,可能会发现额外的风险因素和关联.
相关概念视频
01:18Factors Affecting Illness
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness, disability,...
For instance, risk factors are connected to illness, disability,...
01:30Biological Influences on Intelligence
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter more...
01:29Biological Causes of Schizophrenia
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
01:29Alzheimer Disease l: Introduction
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
01:23Alzheimer Disease ll: Pathophysiology
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
01:22Dementia l: Introduction
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...