抗生素失效:除了抗菌素耐药性之外
Cesar de la Fuente-Nunez1, Angela Cesaro1, Robert E W Hancock2
1Machine Biology Group, Departments of Psychiatry and Microbiology, Institute for Biomedical Informatics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Departments of Bioengineering and Chemical and Biomolecular Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA; Penn Institute for Computational Science, University of Pennsylvania, Philadelphia, PA, USA.
抗微生物治疗失败,而不仅仅是耐药性,导致数百万人的死亡. 了解生物膜和败血症等因素对于开发超越抗生素的新疗法来对抗持久性感染至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 每年有数百万人死于感染,治疗失败超过了遗传抵抗力.
- 抗生素失效是临床环境中一个关键的,未被认可的问题.
- 生物膜和败血症显著导致治疗无效.
研究的目的:
- 阐明除了抗生素耐药性之外的临床抗微生物治疗失败的机制.
- 突出生物膜,败血症和微生物群对治疗结果的影响.
- 探索解决抗生素失效的非抗生素治疗策略.
主要方法:
- 文献综述,重点关注抗生素失效的基本机制.
- 分析包括生物膜形成,败血症和微生物组在内的因素.
- 检查当前和新的治疗策略.
主要成果:
- 生物膜中的多药适应性耐药性 (65%的感染) 缺乏经批准的治疗方法.
- 败血症导致19.7%的死亡,尽管使用抗生素,但死亡率很高 (23%).
- 抗生素失效是严重的危机,原因是治疗方法有限,新药可能无效.
结论:
- 迫切需要新型抗感染药物和宿主导疗法来解决抗生素失效的问题.
- 解决生物膜耐药性和败血症管理对于改善患者的治疗结果至关重要.
- 重新思考传统抗生素之外的治疗策略是必不可少的.
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