LncRNA-miRNA相互作用通过调节多种信号通路,参与结直肠癌的发病过程
Shadia Hamoud Alshahrani1, Zeina S M Al-Hadeithi2, Sami G Almalki3
1Medical Surgical Nursing Department, King Khalid University, Khamis Mushate, Saudi Arabia.
Pathology, research and practice
|November 4, 2023
概括
长非编码RNAs (lncRNAs) 和微RNAs (miRNAs) 调节癌症基因. 针对它们的相互作用显示了结直肠癌 (CRC) 治疗的前景,但需要解决特异性和输送等挑战.
科学领域:
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
- 在瘤学瘤学.
背景情况:
- 长非编码RNAs (lncRNAs) 作为分子海绵或直接与microRNAs (miRNAs) 相互作用.
- 微RNA (miRNA) 是基因表达的关键调节者,包括瘤基因和瘤抑制基因.
- 毫米RNAs的失调与各种癌症的发展和进展有关,包括结直肠癌 (CRC).
研究的目的:
- 探索针对结直肠癌 (CRC) 中的lncRNA-miRNA轴的治疗潜力.
- 确定阻碍基于lncRNA-miRNA治疗CRC临床应用的关键挑战.
主要方法:
- 该研究审查了lncRNAs和miRNAs相互作用并影响基因表达的机制.
- 它分析了lncRNA-miRNA轴在癌症相关基因和CRC病变发生的背景下的作用.
- 该研究综合了针对这一轴的治疗策略的当前知识.
主要成果:
- LncRNAs可以通过海绵或直接相互作用来调节miRNA活动,从而影响与癌症相关的基因表达.
- miRNA失调是CRC发病和进展的一个重要因素.
- 针对lncRNA-miRNA轴为CRC治疗提供了一个有前途的途径.
结论:
- lncRNA-miRNA轴对结直肠癌 (CRC) 具有显著的治疗潜力.
- 克服与向特异性,交付,耐药性,安全性和成本效益相关的挑战对于临床翻译至关重要.
- 需要进一步的研究来优化这些策略,以改善CRC患者的治疗结果.
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