来自两个鼻孔的气味表征在人体皮质皮质中暂时分离
Gülce Nazlı Dikeçligil1, Andrew I Yang2, Nisha Sanghani1
1Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Current biology : CB
|November 4, 2023
概括
人类的大脑是人类的大脑.
科学领域:
- 神经科学是一个神经科学.
- 嗅觉系统 嗅觉系统
- 感官处理 感官处理
背景情况:
- 人的嗅觉系统利用来自左鼻和右鼻的两个不同的感官输入通道.
- 初级嗅觉皮层 (piriform cortex [PC]) 对于处理气味信息至关重要.
- 目前尚不清楚PC是否集成或分别编码来自每个鼻孔的气味刺激.
研究的目的:
- 为了研究初级嗅觉皮层 (PC) 如何编码来自个体鼻孔的气味信息.
- 为了确定左和右鼻孔的气味输入是否在PC中被处理为集成或单独的刺激.
主要方法:
- 内脑电图 (iEEG) 信号直接从人类PC中记录下来.
- 试验对象执行了一项气味识别任务,气味传递到左,右或两个鼻孔.
- 机器学习被用来分析气味识别编码的时间动态.
主要成果:
- 单鼻孔的气味输入到ipsilateral鼻孔被编码大约480ms比反侧输入更快.
- 在双鼻腔气味采样过程中,气味信息出现在两个时间上不同的时代.
- 第一个时代与ipsilateral气味表示相关,第二个时代与contralateral表示相关.
结论:
- 状皮质 (PC) 保持了来自每个鼻孔的气味输入单独的神经表征.
- 这种分离是通过在PC内的神经活动的时间分离来实现的.
- 这种嗅觉编码机制允许在单次吸入中解析单鼻和双鼻气味信息.
相关概念视频
Olfaction
44.4K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
44.4K
Physiology of Smell and Olfactory Pathway
8.6K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
8.6K
Olfactory Receptors: Location and Structure
9.3K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.3K
Nose and Nasal Cavity
2.6K
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
2.6K
Association Areas of the Cortex
5.4K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
5.4K
Motor and Sensory Areas of the Cortex
3.9K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
3.9K


