相关实验视频
Updated: Jul 11, 2025

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
Published on: February 28, 2021
布普伦诺芬对比迪克洛芬雅缓解急性胰腺炎的疼痛:双盲随机对照试验
Mayank Saini1, Jayanta Samanta2, Antriksh Kumar2
1Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
与迪克洛芬雅克相比,布普伦诺芬是治疗急性胰腺炎 (AP) 疼痛的更有效和同样安全的止痛药. 这种阿片类药物在AP患者中提供卓越的疼痛缓解和更长的无疼痛间隔.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 急性胰腺炎 (AP) 疼痛管理通常涉及非类固醇抗炎药物 (NSAID) 和阿片类药物,但最佳选择仍然不清楚.
- 这项研究直接比较了布普伦诺芬 (阿片类药物) 和迪克洛芬雅 (NSAID) 的疗效和安全性,用于AP的止痛.
研究的目的:
- 为了确定在急性胰腺炎中治疗疼痛的首选止痛药.
- 在AP患者中比较静脉注射布普伦诺芬与静脉注射迪克洛芬的止痛效果和安全性.
主要方法:
- 一个双盲,随机对照试验,涉及AP患者被分配接受静脉注射迪克洛芬或静脉注射布诺芬.
- 芬太尼,通过患者控制的止痛药物,作为救援药物. 主要终点是需要的救援芬太尼尔剂量的差异.
主要成果:
- 与迪克洛菲纳克相比,接受布普伦诺芬的患者需要显著减少救援芬太尼 (130μg与520μg相比;P<.001).
- 布普伦诺芬组经历了更长的无痛间隔 (20小时与4小时相比;P < .001) 和更大的视觉模拟量表 (VAS) 疼痛减轻.
- 布普伦诺芬和迪克洛芬纳克组之间的不良事件概况是可比的.
结论:
- 与狄克洛芬雅相比,布普伦诺芬在急性胰腺炎的疼痛管理中表现出更高的疗效.
- 布普伦诺芬与迪克洛菲纳克一样安全用于AP止痛,包括在中度严重或严重胰腺炎患者中.
更多相关视频
05:39Acupoint Needle-Embedding Combined with Ironing Therapy for Postoperative Pain After Anal Surgery
Published on: June 23, 2023
07:10Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
Published on: April 1, 2022
相关概念视频
Acute Pancreatitis II: Clinical Manifestations and Management
Chronic Pancreatitis II: Collaborative Care
Assessment:
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Analgesia and Pain Management
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include: