短链化 (SCCP) 暴露和2型糖尿病风险:在中国东部开展的一项基于人口的病例控制研究
Gaoxin Zhang1, Qinghua Zhang2, Xiaoling Guan3
1State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
The Science of the total environment
|November 4, 2023
概括
人类接触短链化 (SCCPs) 与2型糖尿病的风险增加有关. 暴露于SCCP也会破坏脂质代谢,特别是在男性和肥胖个体中.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 持续有机污染物被怀疑会增加2型糖尿病的风险.
- 对短链化 (SCCPs) 和人类2型糖尿病风险的研究是有限的.
研究的目的:
- 调查SCCP暴露与2型糖尿病风险之间的关联.
- 探索SCCP暴露,血糖生物标志物和血清脂质参数之间的相关性.
主要方法:
- 一项涉及中国东部山东省344名参与者的病例控制研究.
- 测量和分析了血清SCCP水平与2型糖尿病的关联.
- 统计分析包括混调整,分层分析和调解分析.
主要成果:
- 在所有参与者的血清样本中检测到SCCP.
- 对C10-CPs,C11-CPs和 ΣSCCPs的暴露与2型糖尿病风险有关.
- 对SCCP的暴露与总胆固醇,LDL-C和总脂质水平呈正相关,特别是在女性中.
- 确定LDL-C和TC是SCCP-糖尿病关联中的显著调解者.
结论:
- 人类接触SCCP可能会增加患2型糖尿病的风险.
- 暴露于SCCP可以破坏正常的脂质代谢,导致糖尿病风险.
- 针对性干预可能是必要的 SCCP 暴露率高的人群.
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