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在单边突然的神经神经听力损失中,功能性到结构性可塑性:神经成像证据

Yu-Ting Li¹, Ke Bai¹, Gan-Ze Li¹

¹Department of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an 710038, Shaanxi, China.

|November 4, 2023

概括

突发感应神经听力损失 (SSNHL) 导致大脑变化,从功能连接的改变开始,进展到神经血管合和大脑体积的减少. 早期干预可能会改善结果.

科学领域:

神经科学是一个神经科学.
放射学放射学是一门学科.
听力学听力学是指听力学.

背景情况:

在长期单侧耳聋中已知皮质可塑性,但突然感觉神经听力损失 (SSNHL) 的短期影响尚不清楚.
了解这些早期变化对于及时干预和改善患者预后至关重要.

研究的目的:

通过综合神经成像来调查短时间SSNHL患者的时大脑变化.
检查不同SSNHL阶段的动态功能网络连接 (dFNC),神经血管合 (NVC) 和区域大脑体积的变化.

主要方法:

病例-队列研究涉及38名SSNHL患者和44名健康对照 (HC).
神经成像分析包括对dFNC状态,NVC和大脑区域体积的评估.
患者被分为早期 (1-6天),中期 (7-13天) 和晚期 (14-30天) 的发病后阶段.

主要成果:

早期的SSNHL在dFNC中显示了缓慢的状态过渡.
中期和晚期阶段在听觉皮层呈现下降的NVC.
晚期SSNHL显示左侧中间上额头 (SFGmed) 的体积显著减少,与疾病持续时间和预后相关.

结论:

在第一个月内,SSNHL诱导了从功能性到结构性大脑变化的进展.
这些神经成像发现与治疗反应和听力恢复相关,突显了早期治疗的重要性.

关键词:

皮质的可塑性皮质的可塑性动态功能网络连接能力 (dFNC)神经血管合 (NVC) 是一种神经血管合.突发的感觉神经听力损失 (SSNHL)基于voxel的形态测量 (VBM) 分析分析.

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Neuroplasticity

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