单极和双极抑郁症患者的系统性炎症和氧化应激标志物:一项大规模研究
Yanyan Wei1, Huanqin Gao1, Yanhong Luo2
1Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China.
Journal of affective disorders
|November 4, 2023
概括
炎症标志物如中性粒细胞/HDL比率 (NHR) 和单细胞/HDL比率 (MHR) 在单极抑郁症 (UD) 和双极抑郁症 (BD) 之间有所不同. 这些标志物还可以将精神病与非精神病UD患者区分开来,表明它们在抑郁症病理生理学中的作用.
科学领域:
- 生物化学 生物化学
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 中性细胞/HDL比率 (NHR),淋巴细胞/HDL比率 (LHR),单细胞/HDL (MHR),血小板/HDL比率 (PHR),中性细胞/ALB比率 (NAR) 和血小板/ALB比率 (PAR) 是已确定的系统性炎症和氧化应激的标志物.
- 有限的研究已经探索了这些炎症和氧化应激标记与单极抑郁症 (UD) 和双极抑郁症 (BD) 的关联,特别是在精神病症状方面.
研究的目的:
- 调查NHR,LHR,MHR,PHR,NAR和PAR与UD和BD之间的关联.
- 检查这些标记在区分UD和BD中的作用.
- 分析UD和BD患者中这些标志物与精神病症状之间的关系.
主要方法:
- 一项涉及6297名UD患者,1828名BD患者和7630名健康对照者的横截面研究.
- 在诊断组 (UD,BD,健康对照组) 中比较NHR,LHR,MHR,PHR,NAR和PAR水平.
- 对UD,BD和精神病症状的影响因素的分析,包括这些特定的比率.
主要成果:
- 这些比率在诊断组之间观察到明显的变化模式.
- 与UD和健康对照组相比,BD组显示出更高的NHR,LHR,MHR,NAR和更低的PAR.
- UD组的MHR比健康对照组更高. 精神病性UD患者比非精神病性UD患者有更高的NHR,LHR,MHR和NAR. 与UD相比,较高的LHR,MHR,NAR和较低的PAR是BD的风险因素.
结论:
- 在UD和BD患者之间存在着炎症和氧化应激概况的显著差异.
- 这些标志物在UD和BD中区分具有和没有精神病症状的个体.
- 炎症和氧化应激在UD和BD的病理生理学中起着至关重要的作用.
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