AgRP神经元活动促进感官和营养信号之间的关联,以引导品味偏好
Nathaniel T Nyema1, Aaron D McKnight1, Alexandra G Vargas-Elvira2
1Monell Chemical Senses Center, Philadelphia, PA 19104, USA; University of Pennsylvania, Philadelphia, PA 19104, USA.
Molecular metabolism
|November 4, 2023
概括
阿古蒂相关蛋白 (AgRP) 神经元活动令人惊地增强了味道营养学习,具有性别特异性机制. 这些神经元跟踪和更新食物线索及其营养价值之间的关联,影响饮食行为.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 代谢神经科学 代谢神经科学
背景情况:
- 食物感官线索和营养价值之间的学习关联显著影响饮食行为.
- 基础上的神经回路风味-营养素学习 (FNL) 尚未完全理解.
- 表达阿古蒂相关蛋白 (AgRP) 的神经元是养行为的关键驱动因素.
研究的目的:
- 研究AgRP表达神经元在调解风味营养学 (FNL) 中的作用.
- 检查食物摄入期间AgRP神经元的光遗传刺激如何影响FNL.
- 用纤维光度测量来确定内源AgRP神经元活动如何跟踪口味-营养关联.
主要方法:
- 在小鼠的食物摄入过程中,AgRP神经元的光遗传刺激.
- 纤维光度测量用于记录内源AgRP神经元活动.
- 分析风味偏好发展和消费模式.
主要成果:
- 在FNL期间的Tonic AgRP神经元活动强化了风味偏好,与预期相反.
- 在男性中,AgRP神经元活动增加了风味消耗,加强了这种关联.
- 在女性中,AgRP神经元活动增强了独立于消费的风味-营养素偏好,这表明奖励价值增加.
- 在体内神经活动分析显示,AgRP神经元动态跟踪两个性别的风味-营养关联.
结论:
- AgRP神经元活动以性别依赖的方式增强了风味-营养的关联.
- AgRP神经元积极跟踪并快速更新感官线索与营养价值之间的学习关联.
- 这些发现为AgRP神经元如何整合感官和营养信号以加强食物提供了新的见解.
相关概念视频
The Physiology of Taste
3.9K
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
3.9K
Gustation
48.1K
Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
48.1K
G-Protein Gated Ion Channels
4.6K
GPCRs are primarily responsible for our sense of smell, taste, and vision. The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
Sensory...
4.6K
Regulation of Food Intake
247
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
247
Taste Buds and Receptors
2.1K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
2.1K
Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K


