在用低GWP推进剂配制的计量剂量吸入器中,容器和执行器沉积
Daniel J Duke1, Lingzhe Rao1, Alan Kastengren2
1Laboratory for Turbulence Research in Aerospace & Combustion (LTRAC), Department of Mechanical & Aerospace Engineering, Monash University, Australia.
International journal of pharmaceutics
|November 4, 2023
概括
在压力计量剂量吸入器 (pMDIs) 中的药物沉积随着新的低全球变暖潜力 (GWP) 推进剂而变化. 了解这些推进剂-药物相互作用对于开发有效的pMDI配方至关重要.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 分析化学 分析化学
背景情况:
- 压力计量剂量吸入器 (pMDI) 配方开发面临的挑战是药物粘附于设备组件.
- 低全球变暖潜力 (GWP) 推进剂由于对药物溶解度和推进剂化学的理解不足,导致了新的配方复杂性.
研究的目的:
- 通过使用新型低GWP推进剂,研究pMDI组件中的药物沉积模式.
- 评估不同推进剂 (HFA134a,HFA152a,HFO1234ze(E)) 对溶液和悬浮配方中药物分发的影响.
主要方法:
- 利用同步子辐射X射线光光谱学来量化pMDI组件中的药物含量.
- 检查了酸和硫酸的替代溶液和悬浮配方,用标准组件装在容器中.
主要成果:
- 在pMDI门和执行器内的药物分布因不同的推进剂而有显著差异.
- HFO1234ze(E) 显示溶液配方的门关闭区域的沉积增加,减少了执行器沉积.
- HFA152a在悬浮配方中表现出最大的差异,这是由于其较低的比重.
结论:
- 推进剂的化学和物理特性显著影响pMDIs中的药物沉积.
- 这些发现对于使用低GWP推进剂的pMDI产品的成功开发至关重要.
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