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[捐赠者平价对卵细胞捐赠结果的影响]
Philippine Gruchala1, Laura Keller2, Bérengère Ducrocq-Caux2
1Service d'AMP, CHU de Lille, université de Lille, 59000 Lille, France.
Gynecologie, obstetrique, fertilite & senologie
|November 4, 2023
概括
卵子捐赠的成功率是相似的,无论捐赠者是否先前分娩过. 这一发现表明,在接受生育治疗的夫妇中,捐赠者平价并不影响卵细胞捐赠的有效性.
科学领域:
- 生殖医学 生殖医学
- 人类游戏细胞捐赠
- 在体外受精过程中受精.
背景情况:
- 法国允许自2015年以来从未繁殖过的个人捐赠性球体.
- 这一政策变化增加了卵细胞捐赠,但接受者夫妇的等待时间仍然很长.
- 基于捐赠者平等性来比较结果对于优化捐赠计划至关重要.
研究的目的:
- 为了比较从无卵性 (从未分娩) 与非无卵性捐赠者的卵细胞捐赠的临床和生物学结果.
- 评估捐赠者平价对卵细胞采集和怀孕成功率的影响.
主要方法:
- 从2016年1月到2019年12月,在里尔大学医院进行了一项单心回顾性观察性研究.
- 对185名捐赠者进行了表型特征和捐赠结果分析 (66名无卵性,119名非无卵性).
- 数据包括284个ICSI周期的卵细胞产量,成熟率和怀孕成功率.
主要成果:
- 无卵性捐赠者比无卵性捐赠者更年轻.
- 每个周期的平均卵细胞产量为11.5个,成熟卵细胞为7.8个.
- 早期怀孕率 (55.6%与50.8%) 和持续怀孕率 (49.2%与42.1%) 在无卵性和非无卵性捐赠者之间没有显著差异.
结论:
- 捐赠者平价似乎没有影响卵子捐赠的成功率.
- 这些发现表明,无卵性和非无卵性女性都可以成为有效的卵子捐赠者.
- 这些信息可以帮助制定捐赠者选择标准,并可能减少夫妇的等待时间.
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