在父母干预期间,有行为问题儿童的白质迅速发生变化
Suzanne O' Brien1, Arjun Sethi2, James Blair3,4
1Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. suzanne.o'_brien@kcl.ac.uk.
Translational psychiatry
|November 5, 2023
概括
在行为问题 (CP) 中的大脑异常可能会逆转. 父母干预减少了CP男孩的未切割 (UF) 微观结构差异,特别是那些具有改善无无情 (CU) 特征的男孩.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 异常的未切割 (UF) 微观结构与精神病症和行为问题 (CP) 有关,特别是无情无情的 (CU) 特征.
- 目前尚不清楚这些脑部异常是永久性的还是可逆性的.
研究的目的:
- 调查父母干预后CP症状的减少是否与UF微观结构完整性的变化有关.
- 确定CP症状或CU特征的临床反应是否解释了UF微观结构的改变.
主要方法:
- 扩散张力成像 (DTI) 曲谱被用来评估UF中的微结构差异 (平均扩散率和辐射扩散率).
- 该研究包括43名典型发育 (TD) 的男孩和67名患有CP的男孩,在14周的育儿干预之前和之后进行评估.
主要成果:
- 与干预前的TD男孩相比,患有CP的男孩表现出增加的UF平均扩散率和辐射扩散率.
- 干预后,CP组显示辐射扩散率和平均扩散率显著降低.
- 这些微观结构变化主要与CU特征的改善有关,而不是CP症状.
结论:
- 这些发现表明,行为问题儿童未切割囊中的微观结构异常可能是可逆的.
- 家长的干预措施可能会对CP儿童的大脑结构产生积极的影响,特别是那些表现出减少无情无情的特征的儿童.
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