睡眠不足和轮班工作与英国生物库参与者的血压升高和炎症有关
Monica Kanki1,2, Artika P Nath3, Ruidong Xiang3
1Cardiovascular Endocrinology Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Nature communications
|November 5, 2023
概括
扰乱昼夜节律,包括睡眠质量差和夜班工作,与高血压有关. 这些关联表明对血压调节的潜在因果作用.
科学领域:
- 时间生物学 时间生物学
- 心血管健康 心血管健康
- 流行病学 流行病学
背景情况:
- 扰乱昼夜节律与高血压和心血管疾病有关.
- 之前的研究已经产生了不一致的结果,并且缺乏对子组分析的力量.
研究的目的:
- 调查昼夜节律扰乱行为与血压 (SBP,DBP) 和炎症标志物之间的联系.
- 为了分析这些协会在一个大队的成年人与欧洲白人英国血统.
主要方法:
- 使用了英国生物库队列 (>35万成年人).
- 评估了睡眠行为 (睡眠时间,质量,时间型,午睡,轮班工作) 和血压之间的关联.
- 采用线性回归和两个样本的门德尔随机化 (MR) 分析.
主要成果:
- 观察到睡眠时间和SBP/DBP之间的U形关系,最明显的是低炎症.
- 睡眠质量差和永久夜班工作与SBP/DBP积极相关.
- 核磁共振分析支持各种睡眠参数对SBP/DBP的潜在因果作用.
结论:
- 循环节律扰乱行为与男性和女性的SBP/DBP调节有积极的关联.
- 这些关联在很大程度上独立于年龄和BMI.
- 研究结果强调了昼夜健康对心血管调节的重要性.
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