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Updated: Jul 11, 2025

Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)
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Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)

Published on: August 9, 2024

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由LRRC8A形成的体积调节离子通道控制的细胞体积微调T细胞激活和功能

Yuman Wang1, Zaiqiao Sun2, Jieming Ping1

  • 1Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Nature communications
|November 5, 2023
PubMed
概括

细胞体积调节,特别是通过LRRC8A通道,对于最佳的T细胞激活和功能至关重要. 这一过程确保了适当的T细胞受体信号密度,影响免疫力和T细胞发育.

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