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甲状腺内胸腺癌:对22例病例的临床病理学分析
1Department of Pathology, National Clinical Research Centre for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Centre for Cancer, Tianjin Medical University Cancer Institute and Hospital, Huanhu West Road, Hexi District, Tianjin 300060, China.
Annals of diagnostic pathology
|November 5, 2023
概括
甲状腺内胸腺癌 (ITTC) 是一种罕见的癌症. CD5和CD117联合表达有助于诊断,高的PD-L1表明免疫检查点抑制剂可能对ITTC治疗有效.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 甲状腺内胸腺癌 (ITTC) 是一种非常罕见的甲状腺恶性瘤,对其了解有限,没有确定的治疗方案.
- 由于ITTC病例稀少,需要进行全面的临床病理学分析,以指导未来的研究和治疗策略.
研究的目的:
- 阐明甲状腺内胸腺癌 (ITTC) 的临床病理学特征.
- 通过检查蛋白质表达和瘤标记物来确定ITTC的潜在治疗点.
主要方法:
- 对22名ITTC患者的临床病理学数据的回顾性审查.
- 免疫组织化学 (IHC) 用于评估ITTC组织中的DNA不匹配修复 (MMR) 蛋白和PD-L1表达.
主要成果:
- 在所有22名ITTC患者 (9名女性,13名男性;平均年龄54.1岁) 进行了手术.
- CK5 / 6,P63,CD5和CD117在普遍表达;TTF1,PAX8,甲状腺蛋白和BRAF V600E是负的.
- 所有瘤都表现出熟练的DNAMMR,对爱斯坦-巴尔病毒 (EBV) 呈阴性,并显示出高的PD-L1综合阳性得分 (CPS) 平均为40.
结论:
- 证实CD5和CD117的同时表达是ITTC的诊断标记物.
- 这个队列中的ITTC具有DNA不匹配修复能力,并且与EBV感染无关.
- 高PD-L1表达表明免疫检查点抑制剂治疗对ITTC患者的潜在疗效.
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