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多发性硬化症与甲状腺疾病的关联:一个元分析

Sushan Gautam¹, Abhinav Bhattarai¹, Sangam Shah¹

¹Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.

Multiple sclerosis and related disorders

|November 5, 2023

概括

患有多发性硬化症 (MS) 的人患甲状腺疾病的风险更高,包括甲状腺功能低下症和自身免疫性甲状腺疾病. 这种增加的风险在患有MS的女性中尤为明显.

科学领域:

神经学神经学
免疫学免疫学免疫学
内分泌学在内分泌学.

背景情况:

多发性硬化症 (MS) 是一种自身免疫性疾病,其特征是T细胞介导的炎症.
多发性硬化和甲状腺疾病之间的联系是复杂的,并产生了各种各样的研究结果.
澄清MS和甲状腺疾病之间的关联对于理解疾病机制和管理至关重要.

研究的目的:

进行元分析,澄清各种甲状腺疾病与多发性硬化症 (MS) 之间的关联.
调查MS患者甲状腺疾病的患病率.
探索MS-甲状腺疾病协会中的潜在性别特异性差异.

主要方法:

我们对PubMed,谷歌学者,ScienceDirect和科学网进行了系统的电子搜索.
用随机效应模型进行了元分析,根据甲状腺疾病亚型进行了亚组分析.
进行了出版偏差和敏感性分析,以确保研究结果的可靠性.

主要成果:

分析包括13项研究,包括13012例多发性硬化病例和56850例对照.
患有多发性硬化症的个体显示,甲状腺功能低下症 (OR:2.29) 和自身免疫性甲状腺疾病 (OR:1.70) 的患病率明显更高.
在MS患者中,甲状腺疾病的总体患病率较高 (OR: 1.60),在MS患者中观察到女性的风险明显增加 (OR: 2.38).

结论:

甲状腺疾病和多发性硬化症之间存在显著的关联,这表明MS患者甲状腺疾病的风险增加.
性别起着重要作用,MS的女性患上甲状腺疾病的患病率更高.
这些发现增强了对MS-甲状腺疾病相互作用的理解,为临床实践和未来研究提供了信息.

关键词:

协会协会协会协会协会进行元分析分析.多发性硬化症是多发性硬化症.流行程度流行程度甲状腺是什么?甲状腺是什么?

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