在急性缺血性中风1年后,D-Dimer与纤维素素比对功能性结果的潜在预测值:一项纵向研究
Qingxia Lin1, Dongdong Zhou2, Yifan Cheng3
1Department of Psychiatry, Wenzhou Medical University First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Gerontology
|November 5, 2023
概括
在急性缺血性中风 (AIS) 患者中,D-二分体与纤维素因子比率 (DD/Fg) 可以预测中风后一年的功能不良结果. 在入院时较高的DD/Fg水平表明不利恢复的风险更大.
科学领域:
- 神经学 神经学
- 血液学 血液学 血液学
- 生物标志物 生物标志物
背景情况:
- 作为血栓栓塞事件和中风严重程度的预测指标,D-二聚体与纤维素原比 (DD/Fg) 已被探索.
- 血DD/Fg与急性缺血性中风 (AIS) 后的长期功能结果之间的关联仍然不完全理解.
研究的目的:
- 研究AIS患者在入院时的血DD/Fg水平与一年后的功能性结果之间的关联.
- 确定DD/Fg是否可以作为AIS后功能预后的预测生物标志物.
主要方法:
- 这是一项前性队列研究,涉及454名AIS患者,遵循STROBE指南.
- 使用美国国立卫生研究院中风严重程度尺度 (NIHSS) 评估中风严重程度.
- 使用修改后的兰金尺度 (mRS) 评估一年后的功能结果.
主要成果:
- 在NIHSS得分组中观察到DD/Fg值的显著差异.
- 较高的DD/Fg水平与1年后的功能表现不佳 (mRS 2-6) 有着强烈的关联 (p < 0.001).
- 在中风后一年,DD/Fg独立预测功能预后不佳,即使经过对混因子进行调整 (OR 9.21).
结论:
- 住院时的血DD/Fg水平是AIS患者功能表现不佳的潜在风险预测因素.
- DD/Fg比为缺血性中风后一年的恢复轨迹提供了有价值的预后信息.
- 这种生物标志物可以帮助识别需要更密切监测或干预的高风险个体.
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